Baltimore Orioles at Cleveland Guardians odds, picks and predictions

The Baltimore Orioles (65-46) and Cleveland Guardians (67-42) play the 3rd contest of a 4-game series Saturday. First pitch from Progressive Field is at 7:15 p.m. ET (FOX). Let’s analyze FanDuel Sportsbook’s lines around the Orioles vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Guardians lead 4-1

The Guardians doubled up the Orioles 8-4 in Friday’s game, and Cleveland has now outscored Baltimore 18-7 in the first 2 games of the series.

The Guards have won 5 in a row, averaging 7.0 runs per game (RPG) during the span, while allowing just 2.8 RPG. The Over is 3-1 in the past 4 contests, too.

The O’s have dropped 3 of the past 5 games while going a dismal 5-8 across the previous 13 outings. The Over has connected in both games of this series, and the total has gone high at an 11-1 clip in the past 12 contests while going 14-2 in the past 16 outings.

Orioles at Guardians projected starters

RHP Zach Eflin vs. LHP Joey Cantillo

Eflin (6-7, 4.11 ERA) makes his 21st start. He has a 1.19 WHIP, 1.0 BB/9 and 7.3 K/9 in 116 IP with the Tampa Bay Rays and Orioles.

• Last start: Win, 6 IP, 3 ER, 10 H (1 HR), 0 BB, 7 K in 11-5 home victory vs. Toronto Blue Jays in his team debut Monday
• 2024 road splits: 2-5, 5.32 ERA (66 IP, 39 ER), 1.30 WHIP, .285 opponents’ batting average, 9 BB, 54 K in 8 starts with Rays
• Career vs. Guardians: 0-1, 18.00 ERA (3 IP, 6 ER), 9 H, 1 BB, 3 K in 1 start, a 9-2 home loss Aug. 13, 2023, with Rays

Cantillo (0-0, 8.10 ERA) makes his 2nd career start. He allowed 3 earned runs on 4 hits and 3 walks with 3 K’s in 3 1/3 innings in his debut, a 4-3 victory at the Philadelphia Phillies Sunday.

• 2024 stats with Triple-A Columbus: 1-1, 2.79 ERA (29 IP, 9 ER), 1.48 WHIP, 12.1 K/9 in 8 appearances (7 starts)
• Is starting in place of RHP Tanner Bibee (shoulder)

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Orioles at Guardians odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:15 a.m. ET.

• Moneyline (ML): Orioles -118 (bet $118 to win $100) | Guardians +100 (bet $100 to win $100)
• Run line (RL)/Against the spread (ATS): Orioles -1.5 (+134) | Guardians +1.5 (-162)
• Over/Under (O/U): 8.5 (O: -110 | U: -110)

Orioles at Guardians picks and predictions

Prediction

Orioles 7, Guardians 4

The ORIOLES (-118) are a solid play behind the veteran Eflin, who looks to have a new lease on life after coming over from AL East rival Tampa Bay.

The Guardians (+100) have played well in this series, piling up the offense against Baltimore pitching, but they cannot be trusted behind the rookie Cantillo. The pitching scales are tipped in Baltimore’s favor Saturday.

Obviously, don’t play both the moneyline and the run line. But, if you’re a little less conservative, take ORIOLES -1.5 (+134). Baltimore has 4 wins in the past 7 games, and it won each of those outings by at least 2 runs. So, if you like the O’s to win, you should also like them to get the job done on the run line.

OVER 8.5 (-110) is a strong play, especially with the rookie going up against an angry Baltimore offense which has struggled in the first 2 games of the series.

The Over is on an 11-1 run in the past 12 games for the O’s while going 3-1 in the past 4 outings for the Guardians. Go high, and feel confidently in doing so.

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