Week 1 NFL picks, predictions, best bets from Vegas expert: This 3-team football parlay pays out nearly 6-1

In addition to suffering through a 2-15 season in 2023, the Carolina Panthers were also the worst team in the NFL against the spread. The Panthers were 4-11-2 against the number in 2023 and the NFC South generally struggled. The Falcons were 5-12 against the spread, the Saints were 6-10-1, and the Buccaneers were the only team in the division to turn a profit at 12-7 against the number. Does that mean you should fade the NFC South again in your NFL against the spread picks 2024 or will we see regression towards the mean?

The Saints are 4-point favorites over the Panthers in the latest Week 1 NFL odds and could be popular options as bettors put together their Week 1 NFL parlay picks. Before you make any Week 1 NFL picks or NFL parlays, be sure to see what SportsLine senior analyst Larry Hartstein has to say .

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. Hartstein's weekly Vegas contest selections form the basis of his NFL best bets column, which is 79-48-2 (62.2%, +25.95 units) since its inception in 2022. Anyone who has followed him is way up.

For Week 1, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1. You can only see Hartstein's Week 1 NFL picks at SportsLine .

Top Week 1 NFL picks

We can tell you Hartstein loves the Browns (-2.5) to cover against the Cowboys . It has been an offseason full of drama for Dallas, with Dak Prescott, Mike McCarthy and CeeDee Lamb all seeking contract extensions after winning the NFC East last season.

Now, they'll have a tough matchup against a dynamic Browns defense. Cleveland ranked first in total defense in 2023 and was devastatingly effective on third down, allowing opponents to convert only 29.1% of the time (best in the NFL). Dallas went 1-4 against the spread over its last five games last season while Cleveland covered in four of six, which is a big reason why Hartstein is including the Browns in his Week 1 NFL parlays. See which other NFL parlay picks to make here .

How to make Week 1 NFL parlays

Hartstein also jumped on two other NFL matchups, including backing one team who he says is "poised for greatness." You can only see Hartstein's Week 1 NFL best bets and parlay at SportsLine .

What are Hartstein's top Week 1 NFL picks, and which other NFL matchups should you target for a strong 6-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from the Vegas expert who is up 25.95 units on ATS picks since 2022 , and find out.