2024 Week 1 NFL score predictions, picks today: Expert gives exact scores for all 16 games

With the season approaching, now is the time to start making Week 1 NFL score predictions. Nailing one of those exact NFL picks can lead to gargantuan returns for bettors, but even if you're not thinking about those types of returns, score predictions can help set Week 1 NFL picks against the spread, over/under, money line, NFL props and more. They can also help you isolate the teams to target with NFL survivor picks or NFL office pool picks.

Games on the Week 1 NFL schedule like Packers vs. Eagles, Texans vs. Colts and Vikings vs. Giants are expected to come down to a matter of points if the Week 1 NFL odds are correct. What scores should you expect in those NFL matchups and what about the seemingly more lopsided games like Bengals vs. Patriots or Bills vs. Cardinals? Before you make any Week 1 NFL picks, be sure to see the exact score predictions from SportsLine expert Eric Cohen .

Cohen, a SportsLine NFL expert and host of the Friday NFL props show on SportsLine's YouTube page, evaluated the entire Week 1 NFL slate and delivers score predictions and analysis for each matchup. He finished last season on a 39-28 roll on NFL picks and was profitable for bettors. His exact score predictions were a hit on social media last year and he even hit an exact score in the playoffs, Kansas City's 27-24 upset victory in Buffalo in the AFC Divisional Round. Anyone who followed Cohen's NFL predictions was profitable. You can only see Cohen's Week 1 NFL exact score predictions at SportsLine .

Top Week 1 NFL picks

After diving into all 16 games from the NFL's opening week, Cohen is high on one of those Week 1 home upset picks, the Indianapolis Colts to upset the Houston Texans, 29-26. Using that score prediction, bettors should be targeting Indianapolis both against the spread (+2) and on the money line (+109). That would also help the Over 49 clear with several points to spare.

The Texans were the talk of the NFL offseason after adding big-name veterans such as Stefon Diggs and Joe Mixon. However, the Colts could be one of the NFL's surprise teams this year if quarterback Anthony Richardson is able to bounce back from a shoulder injury and show the kind of promise that made the Colts pick him No. 4 overall in the 2023 NFL Draft. "I think he flourishes in his return," Cohen told SportsLine. See his other Week 1 football score predictions at SportsLine .

How to make Week 1 NFL score predictions

In addition, Cohen is picking an AFC favorite to dominate its Week 1 opponent by more than three touchdowns. Nailing this result is key to making winning Week 1 NFL picks. You can only see it at SportsLine .

Who wins each Week 1 NFL game, and which AFC team throttles its opponent? Visit SportsLine now to get Eric Cohen's NFL Week 1 score predictions, all from the NFL expert who finished on a 39-28 roll last season .