2024 Week 1 NFL score predictions, picks today: Expert enters exact scores for all 16 games

The new NFL schedule opens with Chiefs vs. Ravens in the 2024 NFL Kickoff Game on Thursday, Sept. 5. Ravens vs. Chiefs will be the first of four games between playoff teams on the Week 1 NFL schedule. Lions vs. Rams will be a rematch of a close-fought NFL Wild Card Weekend matchup last season, with Detroit outlasting Los Angeles, 24-23. The Lions will host the Rams again on Sunday Night Football to open the season and are favored by 3.5 in the Week 1 NFL odds, giving you plenty of options for Week 1 NFL score predictions.

Whether you're betting NFL spreads, NFL over/unders or playing any other NFL alternate lines, having a specific score in mind for each game can help you fine-tune your NFL predictions. Before you make any Week 1 NFL picks, be sure to see the exact score predictions from SportsLine expert Eric Cohen .

Cohen, a SportsLine NFL expert and host of the Friday NFL props show on SportsLine's YouTube page, evaluated the entire Week 1 NFL slate and delivers score predictions and analysis for each matchup. He finished last season on a 39-28 roll on NFL picks and was profitable for bettors. His exact score predictions were a hit on social media last year and he even hit an exact score in the playoffs, Kansas City's 27-24 upset victory in Buffalo in the AFC Divisional Round. Anyone who followed Cohen's NFL predictions was profitable. You can only see Cohen's Week 1 NFL exact score predictions at SportsLine .

Top Week 1 NFL picks

After diving into all 16 games from the NFL's opening week, Cohen is high on one of those Week 1 home upset picks, the Indianapolis Colts to upset the Houston Texans, 29-26. Houston won the AFC South in 2023 by way of a Week 18 win over the Colts and is favored by 2.5 in Indianapolis to open the 2024 season, but don't sleep on this Colts roster now that starting quarterback Anthony Richardson is healthy again.

Richardson was the No. 4 overall pick in the 2023 NFL Draft and he showed impressive athletic ability after winning the job and starting the first four games before his season ended because of a shoulder injury. Now he returns to action with a talented young group of skill players and he'll have a chance to lead a Colts roster that is built for success now that they're healthy again. Cohen is predicting a 29-26 win for the Colts in Week 1. See his other Week 1 football score predictions at SportsLine .

How to make Week 1 NFL score predictions

In addition, Cohen is picking an AFC favorite to dominate its Week 1 opponent by more than three touchdowns. Nailing this result is key to making winning Week 1 NFL picks. You can only see it at SportsLine .

Who wins each Week 1 NFL game, and which AFC team throttles its opponent? Visit SportsLine now to get Eric Cohen's NFL Week 1 score predictions, all from the NFL expert who finished on a 39-28 roll last season .