2024 Week 1 NFL picks, odds, best bets from proven model: This five-way football parlay would pay out 25-1

The Week 1 NFL schedule includes several high-profile NFL matchups between playoff teams and division-rivals. Of the 16 NFL games in Week 1, four are between postseason teams from a season ago and three are divisional matchups. That includes Chargers vs. Raiders in Los Angeles, with both teams looking for a breakthrough season to compete with the Chiefs in the AFC West. The Chargers are 3.5-point favorites in the Week 1 NFL odds, but the Raiders won three of four with Antonio Pierce at the helm to end the season and could be one of the popular NFL upset picks to appear in Week 1 NFL parlay picks.

How should you handle that matchup and which Week 1 NFL lines should you target as you put together your Week 1 NFL predictions? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 1 NFL picks at SportsLine .

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. This is a rematch of a playoff game from a season ago, with Detroit winning 24-23 on its way to making the NFC Championship Game for the first time in over 30 years.

Now, the Lions will also get the rematch at home on Sunday Night Football in Week 1, and Dan Campbell's roster looks improved after Detroit spent its first two picks in the 2024 NFL Draft to improve the secondary. Those improvements and home-field advantage are big reasons why the model has the Lions winning in well over 50% of simulations. See which other NFL parlay picks to make here .

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations. You can only see the model's NFL Week 1 best bets and parlay at SportsLine .

What are the model's top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks , and find out.