2024 Week 1 NFL score predictions, picks today: Expert gives out exact scores for all 16 games

The top two picks in the 2024 NFL Draft will start in Week 1, as Caleb Williams will be under center for the Bears and Jayden Daniels will start for the Commanders. Both players won the Heisman Trophy, college football's most prestigious award, and will try to transition their success to the pro game. Williams opens at home against the Titans while Daniels opens at the Buccaneers, giving anyone making NFL picks on NFL score predictions plenty to digest. Bo Nix, who was drafted No. 12 by Denver, will also be his team's starter, while Drake Maye will learn from the sidelines in New England. With this year's NFL Draft producing a glut of opening day starting quarterbacks, it adds more intrigue to your NFL bets.

Whether you're betting NFL spreads, NFL over/unders or playing any other NFL alternate lines, having a specific score in mind for each game can help you fine-tune your NFL predictions. Before you make any Week 1 NFL picks, be sure to see the exact score predictions from SportsLine expert Eric Cohen .

Cohen, a SportsLine NFL expert and host of the Friday NFL props show on SportsLine's YouTube page, evaluated the entire Week 1 NFL slate and delivers score predictions and analysis for each matchup. He finished last season on a 39-28 roll on NFL picks and was profitable for bettors. His exact score predictions were a hit on social media last year and he even hit an exact score in the playoffs, Kansas City's 27-24 upset victory in Buffalo in the AFC Divisional Round. Anyone who followed Cohen's NFL predictions was profitable. You can only see Cohen's Week 1 NFL exact score predictions at SportsLine .

Top Week 1 NFL picks

After diving into all 16 games from the NFL's opening week, Cohen is high on one of those Week 1 home upset picks, the Indianapolis Colts to upset the Houston Texans, 29-26. While the Texans look to make it past the second round of the playoffs this season, the Colts are still steaming after losing a Week 18 home matchup against Houston to cost them a playoff spot. With quarterback Anthony Richardson returning from an injury-shortened rookie season, Indianapolis is finally able to pair their speedy QB with star running back Jonathan Taylor.

In Week 18 against the Texans, Taylor rushed for 188 yards and a touchdown on 30 carries in the team's narrow defeat. He and Richardson did not see much time on the field due to a combination of a holdout plus injuries. While both teams look to exceed their win totals from last year but the presence of home field advantage and Richardson's return push Cohen to choose the Colts in this season-opening matchup. See his other Week 1 football score predictions at SportsLine .

How to make Week 1 NFL score predictions

In addition, Cohen is picking an AFC favorite to dominate its Week 1 opponent by more than three touchdowns. Nailing this result is key to making winning Week 1 NFL picks. You can only see it at SportsLine .

Who wins each Week 1 NFL game, and which AFC team throttles its opponent? Visit SportsLine now to get Eric Cohen's NFL Week 1 score predictions, all from the NFL expert who finished on a 39-28 roll last season .