College football odds, picks, predictions for Week 2, 2024: Proven computer backs Oklahoma in best bets

The Week 2 college football schedule begins with a pair of intriguing games on Friday night, as SMU hosts BYU while Northwestern faces Duke. SMU opened the season with a Week 0 win over Nevada , so it enters this matchup with a 2-0 record following a 59-7 win over Houston Christian . The Mustangs are 11.5-point favorites in the Week 2 college football odds via SportsLine consensus, but BYU covered the 17-point spread in its 41-13 win over Southern Illinois last week. Should you back the Cougars with your Week 2 college football bets?

There are a pair of ranked vs. ranked matchups on Saturday, starting with a showdown between No. 10 Michigan (+7.5) and No. 3 Texas at the Big House. Later in the day, No. 14 Tennessee (-8) faces No. 24 NC State in Charlotte for the 2024 Duke's Mayo Classic. The Vols opened at -5.5, but that line has moved in their favor throughout the week. Before locking in any Week 2 college football picks, be sure to see the latest college football predictions from SportsLine's proven model .

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, it has turned its attention to the latest college football odds and Week 2 college football betting lines on the spread, money line, and over/under. Head here to see every pick .

Top college football predictions for Week 2

One of the college football picks the model is high on during Week 2: South Carolina (+10) covers against Kentucky at 3:30 p.m. ET on Saturday. Many bettors are looking to fade the Gamecocks following their narrow win over Old Dominion , but the model has identified value following the early line movement. South Carolina freshman quarterback LaNorris Sellers made his debut last week, completing 10 of 23 passes for 114 yards.

However, it was a fairly conservative gameplan from Shane Beamer, and Sellers flashed his potential with 68 rushing yards and a game-winning touchdown. The Gamecocks also have a reliable running back in Arkansas transfer Raheim Sanders , who rushed for 88 yards and a touchdown against Old Dominion. Kentucky was not able to get a full Week 1 game under its belt due to weather, so the model has South Carolina covering the spread in nearly 60% of simulations. See the rest of its Week 2 college football picks here.

Another prediction: No. 15 Oklahoma (-29) easily covers the huge spread against Houston in a 7:45 p.m. ET kickoff on Saturday. The Cougars struggled during their first season in the Big 12, going 2-7 within the conference and 4-8 overall. They were unable to put that rough campaign behind them last week, getting blown out by UNLV in a game where they closed as 3.5-point home favorites.

This is not going to be an easy spot to bounce back from that performance, as Oklahoma is one of the best teams in the conference and is coming off a 51-3 win over Temple . The Sooners debuted Purdue transfer wide receiver Deion Burks , who caught three touchdown passes on six receptions. Oklahoma has covered the spread in five straight games in September, and the model has the Sooners covering in 60% of the latest simulations. See picks for every other game in Week 2 here.

How to make college football picks for Week 2

The model has also made the call on who wins and covers in every FBS matchup in Week 2, and it's calling for multiple underdogs to win outright. You can only get every pick for every game at SportsLine .

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception , and find out.

College football odds for Week 2

See full Week 2 college football picks, odds, predictions here

Friday, Sept. 6

BYU at SMU (-11.5, 56)

Duke at Northwestern (-2.5, 37)

Saturday, Sept. 7

Texas at Michigan (+7.5, 42.5)

Arkansas at Oklahoma State (-7.5, 62.5)

Kansas State at Tulane (+10, 48.5)

South Carolina at Kentucky (-10, 42.5)

Iowa State at Iowa (-3, 35)

Baylor at Utah (-14.5, 54.5)

Michigan State at Maryland (-9.5, 44)

Virginia at Wake Forest (-2, 57)

South Florida at Alabama (-31, 63.5)

Western Michigan at Ohio State (-38, 54)

Colorado at Nebraska (-7.5, 59)

Houston at Oklahoma (-29, 49)

Tennessee vs. NC State (+8, 61)

Boise State at Oregon (-19.5, 61.5)

Mississippi State at Arizona State (-6.5, 59.5)

Utah State at USC (-28.5, 63.5)