Chicago Cubs at San Francisco Giants odds, picks and predictions

The Chicago Cubs (37-43) and San Francisco Giants (38-42) meet Wednesday for the 3rd game of a 4-game set. First pitch from Oracle Park is slated for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 3-2

Chicago was outscored 10-5 in losing the 1st 2 games of this series, and the Cubs have lost 3 in a row overall. On the road, the Cubs are 4-14 since May 13.

San Francisco went into this series on a 5-game losing streak. The Giants are seeking a 3rd straight win, a would-be first for them since June 5-8.

Cubs at Giants projected starters

RHP Hayden Wesneski vs. RHP Hayden Birdsong

Wesneski (2-4, 3.29 ERA) is lined up for his 4th start and 21st appearance. He has a 1.20 WHIP, 3.3 BB/9 and 8.1 K/9 through 41 IP.

• Last outing: No-decision, 2 relief IP, 1 ER, 2 H, 2 BB, 2 K in 11-1 home loss vs. New York Mets Friday
• 2024 vs. Giants: 0-0, 18.00 ERA (1 IP, 2 ER), 1 H, 4 BB, 1 K in 1 relief appearance of 7-6 home loss June 17
• Career vs. Giants: 0-2, 11.88 ERA (8 1/3 IP, 11 ER), 10 H, 7 BB, 8 K in 1 start and 3 relief appearances

Birdsong is a 22-year-old making his MLB debut.

• Being promoted from Triple-A Sacramento after spending just 2 weeks there
• 2024 stats with Triple-A Sacramento: 1-0, 5.00 ERA (9 IP, 5 ER), 1.56 WHIP, 14.0 K/9 in 2 starts
• Owns a combined 2.51 ERA across 57 1/3 IP at Double- and Triple-A
• Regarded as one of the Giants’ top pitching prospects

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Cubs at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:49 p.m. ET.

• Moneyline: Cubs +105 (bet $100 to win $105) | Giants -125 (bet $125 to win $100)
• Run line (RL)/Against the spread (ATS): Cubs +1.5 (-200) | Giants -1.5 (+165)
• Over/Under (O/U): 7.5 (O: -130 | U: -105)

Cubs at Giants picks and predictions

Prediction

Cubs 4, Giants 3

Lots of pitching uncertainty clouds the picture for this one. Consider partial-unit betting all around with sides and totals.

Right-handers bring out the lesser side of San Francisco’s platoon splits (.678 OPS vs. right-handers). Control could be a weakness for Birdsong, and the CUBS (+105) own a robust 9.8% walk rate against righties.

The bullpens figure to loom large in this one. Chicago’s is better rested amongst the high-leverage arms. TAKE CHICAGO (+105).

A Cubs lean priced out of value range: AVOID.

The Under has prevailed in 7 of Chicago’s last 8 games away from Wrigley Field and 8 of the Cubs’ last 11 at San Francisco.

The Chicago bullpen is well-rested in the back end, and the Giants’ bullpen has put up better numbers at home.

Peg the UNDER 7.5 (-105) with a slight lean.

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