Houston Astros at Seattle Mariners odds, picks and predictions

The Seattle Mariners (52-47) welcome the Houston Astros (51-46) to T-Mobile Park Saturday for the 2nd of their 3-game series. First pitch is set for 9:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Astros vs. Mariners odds and make our expert MLB picks and predictions for the best bets.

Season series: Mariners lead 5-3

The Astros won the series-opening game 3-0, scoring all 3 in the 3rd inning. They closed as a +102 underdog on the moneyline. They have won 4 of their last 6 on the road. Houston is 23-25 in away games this season. It has won 5 of its last 7. The Astros are 53-44 against the spread (ATS) on the season.

The Mariners have been strong at home this season, having a 30-19 record at T-Mobile Park. Despite that, they are just 2-7 over their last 9 at home. Seattle has lost 4 straight and 6 of its last 9, dropping to 2nd in the AL West. The Mariners are 42-57 ATS on the season.

Astros at Mariners projected starters

LHP Framber Valdez vs. RHP George Kirby

Valdez (8-5, 3.66 ERA) makes his 17th start. He has a 1.28 WHIP, 2.9 BB/9 and 7.5 K/9 through 98 1/3 innings.

• Last start: Win, 7 IP, 1 ER, 6 H, 1 BB, 10 K in 9-1 win over the Miami Marlins July 10
• 2024 away splits: 4-3, 3.97 ERA (47 2/3 IP, 21 ER), 1.36 WHIP, 2 HR, 7.0 K/9 in 8 starts
• Career vs. Mariners: 5-3, 3.49 ERA (77 1/3 IP, 30 ER), 1.31 WHIP, 9.1 K/9 in 14 appearances (12 starts)

Kirby (7-7, 3.29 ERA) makes his 21st start. He has a 0.99 WHIP, 1.0 BB/9 and 8.9 K/9 through 117 2/3 innings.

• Last start: Loss, 6 IP, 1 ER, 3 H, 2 BB, 7 K in 2-1 road loss to the Los Angeles Angels on July 13
• 2024 home splits: 5-2, 2.63 ERA (54 2/3 IP, 16 ER), 0.95 WHIP, 1 HR, 10.0 K/9 in 9 starts
• Career vs. Astros: 2-0, 1.57 ERA (28 2/3 IP, 5 ER), 0.98 WHIP, 7.8 K/9 in 5 starts

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Astros at Mariners odds

Provided by FanDuel Sportsbook ; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:25 a.m. ET.

• Moneyline (ML) : Astros +106 (bet $100 to win $106) | Mariners -124 (bet $124 to win $100)
• Run line (RL)/Against the spread (ATS) : Astros +1.5 (-210) | Mariners -1.5 (+172)
• Over/Under (O/U) : 7 (O: -110 | U: -110)

Astros at Mariners picks and predictions

Prediction

Mariners 4, Astros 2

Moneyline

BET MARINERS (-124) .

Kirby has a strong track record against the Astros in his 3-year career and at home this season. The Mariners are 6-3 in his 9 home starts. He has had 2 ER or fewer in 6 of those starts as well. Seattle has been streaky this season but has not had a 5-game losing streak this year, riding a 4-game one now. It has also performed well at home this season.

The Astros have lost 2 of their last 3 on the road and have scored 3 or fewer in 3 straight games. Considering their shaky offensive play and Seattle’s strength at home, back MARINERS (-124) .

Run line/Against the spread

PASS.

The Mariners have been steamed up to a run-line favorite, but Valdez is a quality starter for Houston. Keep it simple with the ML play.

Over/Under

BET UNDER 7 (-110) .

The Astros are 38-55-4 O/U on the season and have gone Under in 3 straight games, scoring 3 or fewer in each and allowing 4 or fewer in each. They have allowed 4 or fewer in 8 straight games.

The Mariners have gone Under in 3 straight as well and are 41-52-6 O/U on the season and have scored 3 runs in their last 3 games combined. With both teams having strong starting options and struggling offensively, back UNDER 7 (-110) .

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