Columbus, OH

A series of experiments with highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses circulating in infected U.S. dairy cattle found that viruses derived from lactating dairy cattle induced severe disease in mice and ferrets when administered via intranasal inoculation. The virus from the H5N1-infected cows bound to both avian (bird) and human-type cellular receptors, but, importantly, did not transmit efficiently among ferrets exposed via respiratory droplets.

Features of H5N1 Influenza Viruses in Dairy Cows May Facilitate Infection, Transmission in Mammals

Blanco, TX

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Brigid Pfeifer

There were a number of celebrities who passed away within the past week, including two notable actresses: Shelley Duvall and Shannen Doherty. Shelley Duvall passed away on Thursday July 11th at her home in Blanco, Texas. The cause of death was complications from diabetes and news of her death was confirmed by her partner Dan Gilroy.

Two Beloved Hollywood Actresses Have Passed Away This Week

New York City, NY

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Cheryl E Preston

Yesterday was the third time this year that an ad stating Chelsea Clinton lives in a beautiful Virginia home popped up on my laptop. My computer did not warn me this was a dangerous site, so this time, I clicked on the link.

Chelsea Clinton is rumored to be living in Virginia but probably still in NYC

Chapel Hill, NC

When I returned to NMAC in April after exactly 30 years, I went down memory lane. April 1994 was a busy time for me. I had turned in my master’s thesis at the University of North Carolina at Chapel Hill and was running the review process for the state health department’s first Housing Opportunities for Persons With AIDS grant applicants and studying for finals, and my friend Phil from Maryland had died of an AIDS-related illness.

Memory Lane

Cover: Alicia Diggs, MPH is driven by a desire to improve the health care system for women and people of color—starting with clinical trials. Inside: A guide to clinical trials for people living with HIV; catching up with Paul Edmonds, one of a handful of people cured of HIV and cancer after a stem cell transplant. Plus: The 2024 POZ HIV Drug Chart.

POZ July/August 2024

This quick-reference chart compares antiretroviral (ARV) options for the treatment of HIV, including adult dosing and dietary restrictions.

2024 HIV Drug Chart

Several studies presented at the Conference on Retroviruses and Opportunistic Infections (CROI) shed light on HIV persistence and strategies for long-term remission. Antiretroviral therapy (ART) keeps HIV replication suppressed, but the virus inserts its genetic blueprints into the DNA of human cells and establishes a long-lasting reservoir that antiretrovirals can’t reach.

HIV Reservoirs and Viral Rebound

North Carolina State

Town Talks

Can You Park in Front of Someone’s Property in North Carolina?. Parking on crowded city streets and neighborhoods can be challenging, and many wonder if it's permissible to park in front of someone’s property. Here's a breakdown of North Carolina's parking rules:

Can I legally park in front of someone’s home? What North Carolina law says

Los Angeles, CA

Dean Goishi, a trailblazing Japanese-American voice for HIV, LGBTQ and Asian and Pacific Islander (API) communities, has died. His passing has been noted in numerous social media posts, but further details have not been reported. Goishi was a cofounder and retired director of Asian Pacific AIDS Intervention Team (APAIT), a...

R.I.P. Dean Goishi, HIV and LGBTQ Advocate for Asian and Pacific Islanders

I recently switched HIV medications. My doctor had been suggesting I make this change for a while now. I was reluctant to do so due to my adherence to the “If it ain’t broke, don’t fix it” perspective. Over the years, that way of thinking has mostly served my health well.

Heart of Gold

Arlington, TX

Some Texans recently took to Facebook to amplify rumors about AIDS spreading in a community swimming pool. To be clear, no cases of HIV transmission via swimming pools have ever been recorded, according to the University of Rochester Medical Center. The Facebook post read: “HOA [homeowners association] Pool Infected with...

HIV Cannot Spread in Pools

A CRISPR-based gene therapy was safe and well tolerated in a Phase I study, but it did not prevent viral rebound after stopping antiretroviral therapy (ART). Antiretrovirals can keep HIV suppressed, but the virus inserts its genetic blueprints into human cells and establishes a long-lasting reservoir that makes a cure nearly impossible. EBT-101, from Excision BioTherapeutics, acts as “molecular scissors” to cut viral DNA out of cells. The study enrolled people on ART with an undetectable viral load. They received a single infusion of EBT-101. Three people who maintained viral suppression 12 weeks later started an analytic treatment interruption. Unfortunately, all three experienced viral rebound. This likely occurred because the gene therapy did not reach all cells harboring latent HIV. However, one recipient was able to maintain viral suppression for four months, longer than it typically takes for the virus to rebound after stopping antiretrovirals. This suggests that CRISPR-based therapies like EBT-101 might play a role in a combination functional cure strategy.

Cure: CRISPR Disappoints

Metabolic dysfunction-associated steatotic liver disease (MASLD)—the new name for non-alcoholic fatty liver disease (NAFLD)—and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH), are responsible for a growing share of advanced liver disease. Linked to obesity and diabetes, fatty liver disease is increasingly recognized as a metabolic condition. Over...

Treatment for Fatty Liver Disease

A unique HIV cure case will be among the scientific highlights of AIDS 2024, the 25th International AIDS Conference, which will take place in Munich, Germany and virtually from 22 to 26 July. For the first time, scientists will share information about the “next Berlin Patient”, who appears to be...

First-of-its-kind HIV Cure Case Among Scientific Highlights at AIDS 2024

Mobile, AL

I found out I was HIV positive in February 2017 in my last semester at the University of South Alabama in Mobile. Ironically, I was taking a class on global health and chose HIV/AIDS as my research topic. I chose it before I knew about my own status. Life is funny. The research was good because it forced me to confront some realities and learn my new normal. I think I reached a place of acceptance earlier than I would have otherwise.

The Best Medicine

According to the World Health Organization (WHO) 2024 Global Hepatitis Report, the number of lives lost due to viral hepatitis is increasing. Viral hepatitis is the second leading infectious cause of death globally—with 1.3 million deaths per year, the same as tuberculosis, a top infectious killer. The report, released...

Viral Hepatitis Deaths Are Increasing

Nebraska State

Omaha, NE

NewsByJoshua

In a recent development, Wellpath has announced layoffs affecting 64 employees in Omaha, Nebraska, following a change in contract that necessitated the closure of its healthcare operations at a specific location.

Surprise layoffs hit Nebraska as an unexpected company downsizes

Charlotte, NC

When it comes to grocery shopping, consumers often debate the prices at different stores. In North Carolina, two chains are particularly known for their higher prices:. Locations: 16 across North Carolina, predominantly in larger cities like Charlotte and Raleigh.

North Carolina Is Home To Two Of The Most Expensive Grocery Stores in America

Chicago, IL

Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

The injectable antiretroviral drug lenacapavir was safe and 100% effective as long-acting HIV pre-exposure prophylaxis (PrEP) among cisgender women in a Phase 3 clinical trial, according to top-line findings released by Gilead Sciences, Inc., the study sponsor. Lenacapavir is administered every six months, making it the most durable HIV prevention method to have shown efficacy in this population.

NIH Statement on Preliminary Efficacy Results of Twice-Yearly Lenacapavir for HIV Prevention in Cisgender Women

NewsBreak

Clues From Bird Flu’s Ground Zero on Dairy Farms in the Texas Panhandle

In early February, dairy farmers in the Texas Panhandle began to notice sick cattle. The buzz soon reached Darren Turley, executive director of the Texas Association...

Clues From Bird Flu’s Ground Zero on Dairy Farms in the Texas Panhandle

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