A CRISPR-based gene therapy was safe and well tolerated in a Phase I study, but it did not prevent viral rebound after stopping antiretroviral therapy (ART). Antiretrovirals can keep HIV suppressed, but the virus inserts its genetic blueprints into human cells and establishes a long-lasting reservoir that makes a cure nearly impossible. EBT-101, from Excision BioTherapeutics, acts as “molecular scissors” to cut viral DNA out of cells. The study enrolled people on ART with an undetectable viral load. They received a single infusion of EBT-101. Three people who maintained viral suppression 12 weeks later started an analytic treatment interruption. Unfortunately, all three experienced viral rebound. This likely occurred because the gene therapy did not reach all cells harboring latent HIV. However, one recipient was able to maintain viral suppression for four months, longer than it typically takes for the virus to rebound after stopping antiretrovirals. This suggests that CRISPR-based therapies like EBT-101 might play a role in a combination functional cure strategy.

Cure: CRISPR Disappoints

The American Cancer Society (ACS) and the American Society of Clinical Oncology (ASCO) today announced an expanded collaboration to make it simpler for patients to find authoritative cancer information online. The partnership between ASCO, the leading organization for cancer care providers, and ACS, the leading patient education, support, and advocacy organization in cancer, will create one of the largest and most comprehensive online resources for credible cancer information, available for free to the public on cancer.org.

American Cancer Society and ASCO Unite to Create One of the Most Comprehensive Online Sources of Credible Cancer Information

People who delay antiretroviral therapy continue to be at higher risk for complications and death years later, apparently due to greater inflammation. The START trial randomly assigned newly diagnosed individuals to begin treatment either immediately or when their CD4 count fell below 350 or they developed AIDS symptoms. People who started immediately had a 57% lower risk of AIDS-related events, serious non-AIDS events or death. The randomized portion of the trial was halted in 2015, but follow-up continued. A START sub-study measured biomarkers of inflammation and blood coagulation. During the randomized study period, the delayed treatment group had higher levels of IL-6 and D-dimer. During 2016–2021, the delayed group had about a 30% higher risk of complications or death despite starting treatment. What’s more, participants with the highest IL-6 and D-dimer levels in both the immediate and delayed groups had about double the risk. These findings emphasize the importance of prompt diagnosis and early treatment.

Treatment: Delayed Treatment

In 1991, as the United States was battling the AIDS epidemic, the country was fighting another enemy abroad. Many front-yard trees were decorated with yellow ribbons in recognition of U.S. military members deployed in Iraq during the Gulf War. Struck by the sight of so many ribbons while driving in upstate New York with his partner Harvey Weiss and artist Frank Moore, costume designer Marc Happel wondered whether a ribbon could be used as a symbol to acknowledge the HIV epidemic.

Launching the Red Ribbon

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Total Apex Sports & Entertainment

Specific zodiac signs in astrology are viewed as homebodies due to the natural traits associated with their astrological profiles. These traits influence their preferences and comfort zones. The homebody tendencies of these zodiac signs develop out of their internal need for comfort, security, and personal space.

4 Zodiac Signs Who Love Staying In

What does it mean to be selfish? According to the Merriam-Webster dictionary, the definition of selfish is the lack of consideration for others; someone concerned chiefly with one's own personal profit or pleasure. You know, people who will do for themselves before they will do for others. People who put their own priorities above everyone else. Do you know people who fit that definition? I am sure we all know at least one, I have known man over the years. Let’s learn what Signs are the most likely to be selfish.

The Top 5 Most Selfish Zodiac Signs

Michigan State

A second human case of highly pathogenic avian influenza (HPAI) A(H5) virus infection has been identified in the state of Michigan. This is the third human case associated with an ongoing multistate outbreak of A(H5N1) in U.S. dairy cows. None of the three cases are associated with the others. As...

CDC Confirms Second Human H5 Bird Flu Case in Michigan

Metabolic dysfunction-associated steatotic liver disease (MASLD)—the new name for non-alcoholic fatty liver disease (NAFLD)—and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH), are responsible for a growing share of advanced liver disease. Linked to obesity and diabetes, fatty liver disease is increasingly recognized as a metabolic condition. Over...

Treatment for Fatty Liver Disease

Georgia State

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Buford, GA

DeanLand

There's been a whole lotta shakin' goin' on in Northwest Georgia over the past 30 days. And, yes, some of it likely has been in the barn. A total of six earthquakes have been recorded in the northernwestern portion of the state over the past 30 days, according to data from the US Geological Survey (USGS).

6 Earthquakes Shake NW Georgia in 30 Days

Arlington, TX

Some Texans recently took to Facebook to amplify rumors about AIDS spreading in a community swimming pool. To be clear, no cases of HIV transmission via swimming pools have ever been recorded, according to the University of Rochester Medical Center. The Facebook post read: “HOA [homeowners association] Pool Infected with...

HIV Cannot Spread in Pools

Adding lemon to your water has many benefits. It helps burn more calories. It also relieves many digestion problems. Lemon’s antiaging properties make it great for the skin. Have a toothache or bad breath? Lemon water can help. If you have tonsil issues, it’s good to gargle lemon water...

Add Lemon to Your Water

California State

Vallejo, CA

California has long been at the forefront of the fight against smoking, but some local officials in the San Francisco Bay Area, backed by activists who are especially concerned about high rates of smoking in the LGBTQ+ community, are spearheading proposals to further restrict how tobacco is sold and where it is smoked.

Urged on by LGBTQ+ Activists, California Cities Weigh Stricter Smoking Rules

Marriage is considered the most sacred phase of a relationship. Not everybody is blessed to have a lasting partner committed to marriage. But do you know this trait can most likely be found through their zodiac sign? That's true. Zodiac signs play a pivotal role in deciding a person's traits, including their willingness to marry.

4 Zodiac Signs Most Likely to Embrace the Joys of Marriage

F a decade, in blog posts and scientific papers and public talks, the psychologist Hal Herzog has questioned whether owning pets makes people happier and healthier. It is a lonely quest, convincing people that puppies and kittens may not actually be terrific for their physical and mental health. “When I talk to people about this,” Herzog recently said, “nobody believes me.” A prominent professor at a major public university once described him as “a super curmudgeon” who is, in effect, “trying to prove that apple pie causes cancer.”

The Fuzzy Science on Whether Fido Is Actually Good for You

This quick-reference chart compares antiretroviral (ARV) options for the treatment of HIV, including adult dosing and dietary restrictions.

2024 HIV Drug Chart

Wednesday, June 5, marks HIV Long-Term Survivors Awareness Day (HLTSAD). It’s an opportunity to celebrate this group of survivors aging with HIV and to also raise awareness of their unique challenges and needs. Search the hashtag #HLTSAD for infographics to share, events to attend and articles to read, such...

HIV Long-Term Survivors Awareness Day 2024

Kansas City, MO

Cats of Kansas City

All of these cats are currently looking for a place to call home and have heard it through the grapevine that you've got some pretty nice digs. If you fancy any of them, consider clicking on their links and getting in touch with their respective shelter. All of these cats are in the greater Kansas City area.

Five cats that would love to move in with you

New York City, NY

The e-Texan

New York – As Trump anticipates his sentencing on July 11th in the New York hush money case, Florida Judge Aileen Cannon made a ruling this Monday. Despite rejecting Trump’s legal team's request to dismiss several charges in the classified documents case, she conceded on a minor point. She removed a portion of the charges that referenced an uncharged allegation, but upheld the other charges.

Legal expert says Trump should not be jailed after New York guilty verdict because he is ‘too old’

Tennessee State

Shelby County, TN

Memphis, TN

In recent years, reported HIV and syphilis cases have surged in. ’s Shelby County, which encompasses Memphis, prompting a response from the Shelby County Health Department (SCHD), reports WREG-TV News Channel 3. According to the Tennessee Department of Health (THD), since 2018, HIV rates have increased by 36%, and syphilis...

"Alarming” Increase in HIV, Syphilis Cases in Tennessee

New Orleans, LA

Lori Tipton is among the growing number of people who say that MDMA, also known as ecstasy, saved their lives. Raised in New Orleans by a mother with untreated bipolar disorder who later killed herself and two others, Tipton said she endured layers of trauma that eventually forced her to seek treatment for crippling anxiety and hypervigilance. For 10 years nothing helped, and she began to wonder if she was “unfixable.”

Psychoactive Drugs Are Having a Moment. The FDA Will Soon Weigh In.

NewsBreak

Unpacking the Interplay Between Autoimmunity and Immunodeficiency

The presence of antibodies that target one of the body’s own proteins was associated with severe infections that typically only occur when a person’s immune system...

Unpacking the Interplay Between Autoimmunity and Immunodeficiency

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