Shield, the first FDA-approved blood test for CRC screening, may offer convenient screening access for those who are at average risk for the disease. The FDA has approved ShieldTM, a noninvasive, blood-based test designed to screen for colorectal cancer (CRC) in individuals 45 years and older who are at average risk of developing the disease, according to a press release from the developer, Guardant Health, Inc.1.

FDA Approves Blood Test for Colorectal Cancer Screening

Researchers found that adults with overweight or obesity lost more weight with tirzepatide than semaglutide in a head-to-head comparison of the medications using electronic medical records data. Results showed that a weight loss of 15% or higher was achieved by 42.3% of the tirzepatide group vs. 18.1% of the semaglutide...

Top in endocrinology: Tirzepatide vs. semaglutide; FDA rejects icodec for diabetes

The FDA’s ODAC mandates phase assessments for NSCLC trials, dendritic cell immunotherapy shows improved survival in pancreatic cancer, and a new blood test for colorectal cancer receives FDA approval. In addition, pembrolizumab plus neoadjuvant chemo proves effective in unresectable HGSC and THIO-cemiplimab combo shows lower toxicity in advanced NSCLC.

The Targeted Pulse: FDA’s ODAC Mandates New Phase Assessment Protocols in NSCLC, Dendritic Cell Vaccine Gains Ground in Pancreatic Cancer, and More

Review of: Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide. Hathaway J, Sha M, Hathaway D, et al. JAMA Ophthalmology, in press 2024. Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) prescribed to assist with weight management in patients with type 2 diabetes (T2D) or those who are overweight/obese, and there have been anecdotal reports of nonarteritic anterior ischemic optic neuropathy (NAION) in patients taking this medication. This single-center, observational study compared patients prescribed semaglutide to matched patients prescribed other medications for diabetes and found a greater risk of NAION in the semaglutide cohort, though additional studies are needed to verify this relationship and causality cannot be inferred.

Semaglutide May Be Associated With an Increased Risk of Developing NAION

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

Kentucky State

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Northern Kentucky Tribune

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

A healthy 38-year-old who began struggling to finish a half-marathon and experienced night sweats, body aches, and COVID-like symptoms learned he was facing stage 4 non-Hodgkin lymphoma. Despite the shocking diagnosis, he plans to remain positive while he fights the cancer. Lymphoma is a blood cancer, specifically of the immune...

Fit, Healthy Man, 38, With Swollen Knee Felt Covid-Like Symptoms for a Month Before Learning He Had Stage 4 Non-Hodgkin Lymphoma

Treatment-induced neuropathy of diabetes (TIND) is a rare but potentially painful complication of diabetes caused by high blood sugar and nerve damage. Treatment-induced neuropathy of diabetes (TIND) is a little-known complication of diabetes that may affect up to 10% of individuals with diabetes. This acute condition occurs due to aggressive...

What to Know About Treatment-Induced Neuropathy of Diabetes (TIND)

North Carolina State

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Town Talks

Eating while driving can be a form of distracted driving, which increases the risk of accidents. However, in North Carolina, NCDOT says don’t eat while driving. Impact: Distracted driving led to 157 deaths and 18,552 injuries in North Carolina in 2020.

Can you eat fast food while driving in North Carolina? Here’s what state law says

Colorado State

Aurora, CO

David Heitz

The Aurora Police Department released a statement on Tuesday on social media to clear up misinformation about an incident involving thousands of migrants. “Misinformation has spread on social media regarding the large gathering on Sunday at Gardens on Havana shopping center,” Aurora PD posted on X. “We recognize that Sunday’s incident was disconcerting and alarming for a large number of our residents and citizens. The purpose of this message is to provide the community with accurate information based on what we know right now.”

Law-abiding Venezuelans watch election results in Aurora, leave behind mess

Sanford, FL

Akeena

Soul food, a favorite from the South, is loved by many Floridians who used to live up North. Florida is home to popular soul food places like Seth's and Happy Soul. Unfortunately, another favorite, Angel's Soul Food in Sanford, has been closed after a state inspection.

Florida soul food restaurant found with debris, "Mold-Like" substance, and raw sewage on the floor

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Data from the SUMMIT clinical trial demonstrated that tirzepatide lowered the risk of negative heart failure outcomes and enhanced symptoms and physical limitations when tested with three different doses. Results from the SUMMIT Phase III clinical trial found that Eli Lilly’s tirzepatide, tested at doses of 5 mg, 10 mg,...

Tirzepatide Shows Statistically Significant Improvements in Reducing Heart Failure Risk, Enhanced Symptoms

Biologics work by targeting proteins that cause inflammation in ulcerative colitis. As a result, certain biologics help decrease flare-ups and complications. There are four types of biologics identified in the treatment of ulcerative colitis: anti-tumor necrosis factor (TNF) agents, integrin receptor antagonists, interleukin inhibitors, and Janus kinase (JAK) inhibitors. Biologics...

4 Types of Biologics Used for Ulcerative Colitis

Denver, CO

In addition to collecting more than 8,000 used needles in the past year from Denver drug users, the Harm Reduction Action Center passed out 10,000 meth pipes and “snort kits,” according to a newsletter sent to its supporters Thursday. They also connected about 1,700 people to medical, mental health and substance abuse treatment.

Denver group hands out 10K meth pipes, ‘snort kits,’ connects 1,700 to treatment annually

Florida State

Jacksonville Today

Republican Donald Trump has a 7-point lead over Democrat Kamala Harris among Florida voters, 49% to 42%, according to a new poll from the University of North Florida. Four percent are backing another candidate, and 6% are undecided or didn’t answer.

New Florida poll: Trump leads; support strong for abortion and recreational weed

Bucks County Beacon

Conservatives have done the United States a huge favor by explaining in detail what they’ll try to do if Donald Trump is reelected. Project 2025 , a “presidential transition project” of the Heritage Foundation, helpfully lays out how a group of former Trump officials would like to transform the country into a right-wing dystopia where the rich thrive and the rest of us die aspiring to be rich.

Project 2025’s Plan to Gut Medicare and Medicaid

More dangerous substances are entering the Denver drug supply, Harm Reduction Action Center warned in a newsletter this week. “The Iron Law of Prohibition posits that as law enforcement becomes more intense, the potency of prohibited substances increases,” HRAC Executive Director Lisa Raville wrote in the newsletter. That is exactly what is happening, she said.

Dangerous substances entering Denver drug supply

South Carolina State

Explore Beaufort SC

The mantis shrimp is one tough customer. Beautiful and deadly are two words you don’t typically use to describe shrimp, but the mantis shrimp is definitely in a class of its own; earning a reputation as the ‘savage boxer of the sea’ and one of the most fearsome creatures in the ocean. And, they're right at home here in South Carolina.

Savage Boxer of the Sea: The Deadly Beauty of Mantis Shrimp

NBC News

Eli Lilly’s drug tirzepatide, sold under the names Mounjaro for diabetes and Zepbound for weight loss, improved symptoms in heart failure patients with obesity, the company said Thursday. The findings add to a growing body of evidence that the GLP-1 drugs, which also include Novo Nordisk’s Ozempic and Wegovy,...

Eli Lilly's tirzepatide cuts heart failure risks, company says

NewsBreak

FDA Grants Afami-cel Accelerated Approval in Advanced Synovial Sarcoma

Afamitresgene autoleucel is now an FDA-approved treatment for patients with advanced synovial sarcoma. The FDA has granted an accelerated approval to Teclera (afamitresgene autoleucel; afami-cel) for...

FDA Grants Afami-cel Accelerated Approval in Advanced Synovial Sarcoma

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