‘How I Met Your Mother’ Actress, Cancer Survivor Cobie Smulders, 42, Says Modeling Career Made Her ‘Uncomfortable’ Before Landing Big TV Roles

Navigating an Ovarian Cancer Diagnosis and Treatment

• “How I Met Your Mother” actress Cobie Smulders, 42, admits that before landing her star-making television role, she worked as a model, and taking photos made her feel “uncomfortable.” However, she says it helped boost her confidence, which aided her ability to land TV roles.
• In the middle of filming “How I Met Your Mother,” Smulders started noticing unusual symptoms such as low energy and fatigue, which kickstarted her journey to learning she was facing early-stage ovarian cancer.
• Ovarian cancer symptoms are harder to detect, especially during its early stages. Symptoms may include feeling bloated or full, pain in the pelvis or abdomen, nausea, vomiting, or changes in bowel habits.
• Ovarian cancer treatment usually involves surgery called a “debulking procedure” that removes most of the tumor. Chemotherapy often follows surgery to get any remaining bits of cancer.
• PARP inhibitors are drugs that treat ovarian cancer at the genetic level. They work by stopping rapidly dividing cancer cells from repairing their own genetic damage, preventing them from replicating.
• Advanced ovarian cancer patients may also turn to a type of antibody-drug conjugate called Elahere (molecular name mirvetuximab soravtansine) that has been shown to help patients live longer without their disease progressing.

“How I Met Your Mother” star Cobie Smulders, 42, made a name for herself on the popular sitcom with her comedic talents. However, before the ovarian cancer survivor gained fame on-screen, she had an “uncomfortable” modeling career she didn’t really enjoy. “I think that to be a good model, you have to actually enjoy having your pictures taken, and I never really did,” Smulders told entertainment outlet FandomWire.

Smulders portrayed “Robin Scherbatsky” on the show, who worked as a rank-and-file news reporter who turned into a morning show host. She dated Josh Radnor’s character, who portrayed “Ted Mosby” on the show, which brought her character onto the show. Although she admits she did not enjoy modeling early on in her career, she says a silver lining in the craft was that it helped give her confidence, which served her well when auditioning for television roles.

Helping Patients Understand Treatment Options for Ovarian Cancer

• Advances in Ovarian Cancer Treatment
• ‘An Important Step Forward’: New Drug Combo Shows Promise For The Treatment of Some Ovarian Cancer
• A Targeted Ovarian Cancer Treatment– The Role of Avastin (Bevacizumab)
• An Extraordinary New Treatment Option for Ovarian Cancer: PARP Inhibitors

‘Something Was Off’

In the middle of “How I Met Your Mother’s television run, Smulders started experiencing unusual symptoms that made her feel as though “something was off,” she previously explained in an essay for Lenny. My energy was low, I was just so tired all the time, and I felt a constant pressure on my abdomen that I could not explain,” she described.

Taking heed of her body’s signaling something was amiss, she went to see her doctor, which led to her ovarian cancer diagnosis. The term ovarian cancer refers to several different tumors that grow in the ovary. Many ovarian cancers begin in the fallopian tubes, and as the fallopian tubes brush over the ovary, these cells stick to the ovaries and form a tumor. Ovarian cancer symptoms usually don’t appear until the cancer has advanced to later stages, making treatment difficult. The signs of ovarian cancer may include feeling bloated or full, pain in the pelvis or abdomen, nausea, vomiting, or changes in bowel habits. What makes identifying these symptoms more difficult is they can mirror symptoms associated with your monthly menstrual cycle. WATCH: Understanding ovarian cancer. Smulders, a mother of two, had to juggle undergoing cancer treatment and keeping up with her work schedule. She was diagnosed in 2008, and around that time, she worked on “The Slammin’ Salmon.” Following treatment, Smulders said she was given a “clean bill of health.” “The thing is, I don’t know if I will ever be free of my cancer – or, to be more specific, free from the fear of my cancer’s return. Still, it has become, for many people, a livable disease, something that you learn to manage. And that’s what I have done,” Smulders said.

Treating Early Stage Ovarian Cancer

Ovarian cancer is called the “cancer that whispers” because women often don’t experience symptoms until their cancer has already reached its late stages, making treatment more difficult. However, when it comes to the standard of care for treating ovarian cancer, surgery is often considered to be the first step. If a doctor is confident that they can remove the ovarian tumor completely without initial cycles of chemotherapy, the doctor will go ahead with a surgical procedure. “If we think we can do that, we do what we call a debulking procedure or cytoreductive surgery,” gynecological oncologist Dr. Rauh-Hain explains. “That’s usually through an open incision.” This surgical procedure often does not remove the tumor entirely. Ovarian cancer patients undergoing the debulking procedure usually undergo chemotherapy after the surgery to make sure the cancerous tissue is fully treated in a process called adjuvant chemotherapy. This process treats microscopic diseases that cannot be seen with the eye, which the clinician knows will persist in the body after an optimal surgical cytoreduction. Dr. Dana Chase , gynecologic oncologist at Arizona Oncology, says that “80% of patients” go into remission after chemotherapy for “at least a period of time.” The standard treatment for ovarian cancer is made up of two drugs working in combination for “initial chemotherapy” — Carboplatin and Paclitaxel. The typical course of chemotherapy is made up of three to six treatment cycles based on what stage of cancer the patient has, but different drugs have different treatment cycles. After initial treatment, patients may receive maintenance therapy to help ensure the cancer does not return. “We use some maintenance therapies with chemo and then continue them after chemo, such as Avastin, while others we use after chemo, such as Olaparib,” Dr. Chase says. WATCH: How PARP inhibitors impact ovarian cancer treatment. PARP inhibitors are options for women as maintenance therapy after the first chemotherapy or platinum-sensitive recurrence or as a treatment for recurrence. PARP inhibitors stop rapidly dividing cancer cells from repairing their own genetic damage, preventing them from replicating. The benefit a woman may see from PARP inhibitors varies greatly, with the biggest determinant being the presence of an inherited or tumor mutation in BRCA. BRCA gene mutation increases a woman’s risk of breast and ovarian cancer. Experts tell SurvivorNet that every woman with ovarian cancer should get a genetic test to determine if they have a BRCA gene mutation because the mutation enables PARP inhibitors to function much more powerfully. The PARP inhibitor Zejula (Niraparib) has been approved by the FDA for all women with newly diagnosed ovarian cancer, irrespective of whether the tumor is HRD. The drug is used after successful treatment with platinum-based chemotherapy, the mainstay chemotherapy for ovarian cancer. The PARP inhibitor Lynparza (Olaparib) is approved for women newly diagnosed with ovarian cancer and with a germline or somatic mutation in BRCA1/2. Rucaparib (brand name Rubraca) is another well-known PARP inhibitor to help treat this cancer.

Advancements in Ovarian Cancer Treatment

Promising advancements have offered new hope to patients who typically haven’t had many options. Remember, many ovarian cancer patients are diagnosed once the cancer has advanced into later stages. Cancer that has spread to other body parts is more challenging to treat. MORE: Treating Recurrent Ovarian Cancer For advanced ovarian cancer that has a tendency to come back and has become resistant to platinum-based chemotherapy , more has to be done during treatment. Cancer that comes back within six months of treatment with a platinum-based chemotherapy drug is called platinum-resistant. If the cancer returns after six months following platinum-based chemotherapy is finished, it is called platinum-sensitive. Women with these stubborn tumors have additional treatment options thanks to advancements in ovarian cancer treatment. The cancer drug Elahere (molecular name mirvetuximab soravtansine) was approved by the Food and Drug Administration (FDA) for certain patients with platinum-resistant disease who had received one to three previous treatments. Dr. Anna Berkenblit , Chief Medical Officer at ImmunoGen, explained to SurvivorNet what Elahere, an antibody-drug conjugate, did for patients in a pivotal trial called MIRASOL. “We have longer progression-free survival, which means the patients are living longer without their cancer progressing. And most importantly, we have demonstrated that patients are living longer,” she said. WATCH: Investigating New Ovarian Cancer Treatments Elahere targets the folate receptor alpha protein located on the tumor cell's surface. It offers effective treatment for a large population of women with advanced ovarian cancer. “It is approved now for patients with high folate receptor alpha level expression, and that’s about 35% to 40% of all ovarian cancer patients,” Berkenblit explained. “Available therapies for these (platinum-resistant) patients are typically single-agent chemotherapies. And now we’ve shown that Elahere is better than the available therapies,” Dr. Berkenblit said. The MIRASOL trial looked at how Elahere performed compared to giving chemotherapy alone in patients with folate receptor alpha-positive platinum-resistant ovarian cancer. In the trial, more than one-third of patients (36%) receiving Elahere (who had previously been treated with the targeted therapy bevacizumab) experienced improved progression-free survival (how long a patient goes without their disease worsening), and more than one-fourth (26%) experienced improved overall survival (how long the patient lives). In another, smaller group of patients who had not previously been treated with bevacizumab, progression-free survival was 34% better, and overall survival was 49% better than when patients received standard chemotherapy.

Questions for Your Doctor

If you have been diagnosed with ovarian cancer and are interested in learning if these new treatments are available to you, ask your doctor a few questions.

• What stage is my ovarian cancer in, and what type do I have?
• Will genetic testing help determine what treatment may be best for me?
• Are there other tests, like for the folate receptor alpha protein, that I can take?
• What are my treatment options based on my results?
• What side effects should I expect from the available treatments?
• If my ovarian cancer is platinum-resistant, what treatment options can I explore?
• Will insurance cover these new cancer drugs?