Isatuximab plus VRd induction before transplant led to better progression-free survival compared with VRd alone, according to data from the GMMG-HD7 phase 3 study. The addition of isatuximab (Sarclisa) to standard-of-care lenalidomide (Revlimid), bortezomib (Velcade), and dexamethasone (isa-VRd) induction therapy followed by hematopoietic cell transplant (HCT) significantly improved progression-free survival (PFS) vs VRd alone among patients with HCT-eligible, newly diagnosed multiple myeloma.1.

Isa-VRd Significantly Improves Survival vs VRd in Transplant-Eligible Myeloma

Following voluntary withdrawal in 2014, denileukin diftitox is now available again for the treatment of patients with cutaneous T-cell lymphoma who have received at least 1 prior systemic therapy. The FDA has approved denileukin diftitox (Lymphir; E7777) for the treatment of patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL)...

FDA Approves Improved Denileukin Diftitox in Cutaneous T-Cell Lymphoma

North Carolina State

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Town Talks

Biscuitville, a North Carolina-based chain, has been named the No. 1 fast-food breakfast spot in the nation by USA Today's 10Best. This accolade comes after a month-long voting period where people across the country chose their favorite breakfast destinations.

North Carolina-based chain ranks No. 1 in the nation for fast-food breakfast. Here’s why

Ohio State

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The Lantern

On Tuesday, licensed Ohio dispensaries began legally selling non-medical marijuana to consumers; however, the drug’s possession, growth and/or usage are still prohibited on Ohio State’s campus. Credit: Jefferee Woo/Tampa Bay Times/TNS [Original caption: Four citizen-led petitions with proposals to update Dallas’ charter hit the 20,000 valid signature threshold to make it on the Nov. 5 election ballot, including one that would ban police officers from arresting or citing people carrying less than four ounces of marijuana.] As of Tuesday, students 21 and older can now legally purchase marijuana in Ohio.

Dispensary sales of recreational marijuana began Tuesday; possession and usage still prohibited on Ohio State’s campus

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

Raleigh, NC

Big cities are known for their hustle and bustle, drawing people in who crave excitement, variety, and entertainment. But bigger isn’t always better, or at least not for Raleigh, North Carolina.

North Carolina City Named The Most Boring Town in the State

NewsNinja

A lady is cautioning others about purchasing budget earrings from Amazon, Shein, and H&M, after she experienced keloid formations on her earlobes due to wearing them. On a TikTok post that has garnered more than 334,000 likes, Sailor Rozema (@sailor.rozema), a content creator, shares a warning with her community of "dangly earring girls": the inexpensive jewelry found in fast fashion can have negative impacts on your well-being.

‘I’ll never be wearing earrings for the rest of my life’: Customer warns against buying from Shein

Camden, NJ

Cornelius, NC

Morristown Minute

CAMDEN, N.J. – Lisa Smith, 61, of Cornelius, North Carolina, has admitted to her role in a fraudulent scheme involving over $3.5 million in Paycheck Protection Program (PPP) loans. U.S. Attorney Philip R. Sellinger announced today that Smith pleaded guilty before U.S. District Judge Karen M. Williams in Camden federal court on July 17, 2024, to a charge of bank fraud conspiracy.

Woman Pleads Guilty to $3.5M COVID Relief Scam

Denver, CO

David Heitz

More dangerous substances are entering the Denver drug supply, Harm Reduction Action Center warned in a newsletter this week. “The Iron Law of Prohibition posits that as law enforcement becomes more intense, the potency of prohibited substances increases,” HRAC Executive Director Lisa Raville wrote in the newsletter. That is exactly what is happening, she said.

Dangerous substances entering Denver drug supply

Kansas State

Missouri State

CJ Coombs

National Center for Missing and Exploited Children (NCMEC) helps to locate missing children. Since July 1, 2024, according to the National Center for Missing and Exploited Children (NCMEC), 174 children have been reported missing in the U.S. Since January 1, 2024, there was a total of 1,445 reported missing in the country.

Missing Missouri children as of July 17, 2024, according to the NCMEC

Colorado State

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

South Carolina State

Colleton County, SC

Explore Beaufort SC

Some beachgoers were in for a surprise this week when a bizarre looking prehistoric fish washed ashore in Colleton County along Edisto Beach at Edisto Beach State Park. It turned out to be an atlantic sturgeon.

Rare Atlantic sturgeon washes ashore on South Carolina beach

New Jersey State

East Orange, NJ

NEWARK, N.J. – Leevander Wade, 44, of East Orange, New Jersey, has been sentenced to 440 months in federal prison for his involvement in three murders linked to a large-scale drug trafficking enterprise. U.S. District Judge Michael E. Farbiarz imposed the sentence on August 1, 2024, following Wade's guilty plea to racketeering conspiracy earlier this year.

NJ Man Sentenced to 36+ Years for Three Drug-Related Murders

Florida State

Uncovering Florida

With hurricane season posing a consistent threat six months out of the year, who would not like a little help getting their home ready for the harsh weather to come? Senate Bill 7028: My Safe Florida Home Program, approved by Governor DeSantis on April 24, 2024, and effective as of July 1, appropriates a one-time total of $200 million from 2024 to 2025 for the purpose of funding hurricane mitigation grants and inspections, as well as outreach and administration costs, to support homeowners in Florida.

DeSantis Signs New Bill Giving $200 Million To Homeowners

Kentucky State

Northern Kentucky Tribune

Gov. Andy Beshear sent a letter to Anne Milgram, administrator for the U.S. Drug Enforcement Administration (DEA) on Wednesday, expressing his support of the U.S. Department of Health and Human Services’ recommendation that the DEA ease restrictions on marijuana.

Gov. Andy Beshear pens letter to DEA in support of easing federal restrictions on marijuana

Tennessee State

John M. Dabbs

NASHVILLE, Tenn. — The Tennessee Department of Health (TDH) has issued a health alert to clinicians statewide following reports of severe acute illnesses and adverse effects of consuming Diamond Shruumz™ brand chocolate bars, cones, and gummies. The warning comes after the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) received reports of serious health issues linked to these mushroom-containing edible products.

Tennessee Health Alert: Severe Illnesses Linked to Diamond Shruumz™ Products

Newark, NJ

NEWARK, N.J. – An Essex County man has been charged with numerous offenses related to narcotics distribution and firearms trafficking. Kyrell Domnie, 39, of Irvington, known by the alias "Fly Ky," was charged by complaint and appeared before U.S. Magistrate Judge Cathy L. Waldor in Newark federal court on July 17, 2024. He remains detained following the hearing.

Convicted Felon Faces Multiple Narcotics and Firearms Charges

New Brunswick, NJ

NEWARK, N.J. -A Middlesex County man, Kenneth Strickland, 57Kenneth Strickland, 57, from New Brunswick, has been convicted of his involvement in a large-scale conspiracy to distribute fentanyl and heroin. U.S. Attorney Philip R. Sellinger announced that Strickland was found guilty on July 29, 2024, of all six counts in a superseding indictment.

NJ Man Convicted in Large-Scale Fentanyl & Heroin Trafficking

Denny's was once a staple of the American diner landscape. In recent years, it has had its ups and downs, especially post-pandemic. The dining habits of people also change. Some customers have a more discerning taste.

Denny's: a legacy of serving customers for over 65 years including 27 locations in Missouri

The Lens

This year’s area of low oxygen in the Gulf of Mexico is larger than average, the National Oceanic and Atmospheric Administration (NOAA) announced on Thursday. The “dead zone” is approximately 6,705 square miles , as measured last week. Within NOAA’s 38 years of measuring the dead zone, this year’s assessment marks the 12th-largest area of low to no oxygen, which can kill fish and marine life.

Gulf ‘dead zone’ larger than average, larger than expected for 2024, scientists announce

NewsBreak

A Deep Dive Into the FDA Approval of Vorasidenib in IDH-Mutant Gliomas

In an interview, Timothy F. Cloughesy, MD, discussed the recent approval of vorasidenib in IDH-mutant gliomas and data from the phase 3 INDIGO trial. On August...

A Deep Dive Into the FDA Approval of Vorasidenib in IDH-Mutant Gliomas

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