Houston Astros at Baltimore Orioles odds, picks and predictions

The Baltimore Orioles (74-55) welcome the Houston Astros (69-58) to Oriole Park at Camden Yards for the 2nd game of a 4-game series Friday. First pitch is set for 7:05 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Astros vs. Orioles odds and make our expert MLB picks and predictions for the best bets.

Season series: Astros lead 4-0

The Astros won the first game of the series 6-0 Thursday, closing as +151 underdogs. They scored 2 runs in the 4th innings and then closed it out with 4 in the 6th.

Houston is 4-2 straight up and against the spread (ATS) in its last 6 games. It has fared well on the road, going 34-29 on the season. Houston is 65-62 ATS.

The Orioles were shut out Thursday for the first time since July 11. Despite sitting 2nd in the AL East, they have struggled over the last week, going 2-5. They are 37-29 at home and 71-58 ATS.

Astros at Orioles projected starters

RHP Hunter Brown vs. LHP Cade Povich

Brown (11-7, 3.82 ERA) makes his 25th start. He has a 1.34 WHIP, 3.3 BB/9 and 9.7 K/9 through 134 1/3 innings.

• Last start: Win, 7 IP, 1 ER, 4 H, 2 BB, 6 K in 6-1 home victory over Chicago White Sox Saturday
• 2024 away stats: 6-4, 4.23 ERA (66 IP, 31 ER), 1.49 WHIP, 10.2 K/9 in 13 appearances (12 starts)
• Career vs. Orioles: 0-2, 8.76 ERA (12 1/3 IP, 12 ER), 1.54 WHIP, 9.5 K/9 in 3 appearances (2 starts)

Povich (1-6, 5.77 ERA) makes his 10th start. He has a 1.58 WHIP, 4.7 BB/9 and 6.4 K/9 through 43 2/3 innings.

• Last start: Loss, 6 1/3 IP, 2 ER, 6 H, 0 BB, 6 K in 5-1 home defeat to Boston Red Sox Saturday
• 2024 home stats: 1-4, 3.58 ERA (32 2/3 IP, 13 ER), 1.41 WHIP, 7.4 K/9 in 6 starts
• Has never faced Astros

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Astros at Orioles odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:40 a.m. ET.

• Moneyline (ML): Astros -118 (bet $118 to win $100) | Orioles +100 (bet $100 to win $100)
• Run line (RL)/Against the spread: Astros -1.5 (+130) | Orioles +1.5 (-156)
• Over/Under (O/U): 9 (O: -106 | U: -114)

Astros at Orioles picks and predictions

Prediction

Astros 5, Orioles 3

BET ASTROS (-118).

The Astros are the far hotter team and have won Brown’s last 2 starts and 5 of his last 7. They have dominated Baltimore this season as well, winning the 4 games a combined 33-13. Houston has won 9 straight road games.

Baltimore’s Povich has lost 4 straight starts and struggled to find his footing in his first MLB season. The Orioles are 4-7 over their last 11 games and have lost 3 of their last 4 at home.

Considering the pitching differences and the recent trends, take ASTROS (-118).

PASS.

There’s not a ton of value here. The Astros as too risky as run-line favorites, having had 2 of their last 4 games end within a single run. Similarly, the Orioles are too expensive and not worth taking as run-line underdogs.

BET UNDER 9 (-114).

The Orioles have gone Under in 5 of their last 6 games and are 2-7 O/U in their last 9. They have scored 4 or fewer runs in 6 of those 9 contests. Baltimore is 1-2 O/U in Povich’s last 3 starts.

The Astros are 0-2 O/U in their last 2 games and 3-7 O/U in their last 10. They have trended Under all season long with a 50-73-4 O/U record. Houston is 1-3 O/U in Brown’s last 4 starts.

Take UNDER 9 (-114).

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