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    San Francisco 49ers at Las Vegas Raiders odds, picks and predictions

    By Jess Root,

    6 hours ago
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    The San Francisco 49ers and Las Vegas Raiders close out their preseasons Friday. Kickoff from Allegiant Stadium is at 10 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Raiders odds, and make our expert NFL picks and predictions.

    The 49ers have split their 2 preseason contests, losing 17-13 at the Tennessee Titans and then beating the visiting New Orleans Saints 16-10 Sunday.

    The Raiders lost 24-23 at the Minnesota Vikings in their preseason opener and then lost 27-12 to the visiting Dallas Cowboys Saturday.

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    49ers at Raiders odds

    Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:15 a.m. ET.

    • Moneyline (ML): 49ers -350 (bet $350 to win $100) | Raiders +260 (bet $100 to win $260)
    • Against the spread (ATS): 49ers -7.5 (-105) | Raiders +7.5 (-115)
    • Over/Under (O/U): 32.5 (O: -115 | U: -105)

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    49ers at Raiders picks and predictions

    Prediction

    Raiders 17, 49ers 13

    The 49ers starters will play briefly. The Raiders won’t play any starters, so the Niners could jump out to a lead early.

    However, the Niners have scored 29 combined points in 2 games.

    That said, the only way to bet the preseason is to bet the plus odds on the moneyline underdog. Preseason is too hard to predict with back-of-roster players, practice-squadders, and guys who won’t be in the NFL in Sept. playing in the 2nd half of these games.

    BET RAIDERS (+260).

    The Raiders have lost by 1 point and by 15.

    The Niners have a 4-point loss and a 6-point win.

    But I say never bet the spread in the preseason. There is too much volatility and unreliability to make an informed bet.

    PASS.

    You have 2 conflicting things going on here.

    The Raiders have allowed no fewer than 24 points in the preseason. The Niners haven’t scored more than 16. Neither of San Francisco’s games surpassed 30 points.

    The Raiders have had 2 games with totals of at least 39.

    BET UNDER 32.5 (-110).

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    For more sports betting picks and tips

    SportsbookWire.com and BetFTW.

    Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

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