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Arizona Cardinals at Buffalo Bills odds, picks and predictions
By Jess Root,
6 hours ago
The Arizona Cardinals open the 2024 regular season on the road against the Buffalo Bills. The game kicks off Sunday at 1 p.m. ET at Highmark Stadium (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Billsodds, and make our expert NFL picks and predictions.
The Cardinals open the season with a healthy QB Kyler Murray and an improved defensive starting lineup. RB James Conner and TE Trey McBride are coming off career seasons. They are coming off a 4-win season and hope to take the next step, being competitive enough to perhaps make the playoffs.
The Bills remade their receiver room and their secondary. They have won the AFC East 4 straight years and hope to be a Super Bowl contender as QB Josh Allen leads the way.
Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Bills -300 (bet $300 to win $100)
Against the spread (ATS): Cardinals +6.5 (-110) | Bills -6.5 (-110)
Over/Under (O/U): 47.5 (O: -105 | U: -115)
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Cardinals at Bills key injuries
Cardinals
S Joey Blount (back) questionable
TE Tip Reiman (ankle) questionable
WR Xavier Weaver (oblique) out
Bills
DE Javon Solomon (oblique) out
DE Dawuane Smoot (toe) questionable
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Cardinals at Bills picks and predictions
Prediction
Bills 30, Cardinals 24
The Cardinals have not won in Buffalo since 1971. They have major question marks on defense with the pass rush, and they were bad against the run last season.
However, the Cardinals were a top-five offense over the final four games of the season and could be better with the addition of rookie WR Marvin Harrison Jr.
It won’t be enough to get the upset, so the Bills should win, and you shouldn’t bet them at -300 because it isn’t worth the action.
PASS.
Arizona’s offense should be able to test the Bills’ new secondary. Allen has thrown 5 INTs in his last 2 season openers, which will keep the game close.
The Cardinals went 9-8 ATS in a season they were 4-13 straight up.
Arizona is likely to have a lot of high-scoring close games. This should be one of them.
BET CARDINALS +6.5 (-110).
Their last matchup in 2020 in Arizona had 62 total points.
Three of the Bills’ final 4 games, including the postseason, has totals of 48 or higher.
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