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    Arizona Cardinals at Indianapolis Colts odds, picks and predictions

    By Jess Root,

    19 hours ago
    https://img.particlenews.com/image.php?url=0nKul7_0v1NlWsG00

    The second week of the preseason continues with the Arizona Cardinals on the road against the Indianapolis Colts Saturday. Kickoff from Lucas Oil Stadium is at 7 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Colts odds, and make our expert NFL picks and predictions.

    The Cardinals opened the preseason with a 16-14 last-second loss to the visiting New Orleans Saints Aug. 10, covering as 3-point underdogs. The Under (38.5) cashed in.

    The Colts also lost their preseason opener, falling 34-30 at home to the Denver Broncos as 1.5-point favorites Sunday as the Over (38.5) hit.

    Cardinals at Colts odds

    Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:40 a.m. ET.

    • Moneyline (ML): Cardinals +110 (bet $100 to win $110) | Colts -135 (bet $135 to win $100)
    • Against the spread (ATS): Cardinals +1.5 (-110) | Colts -1.5 (-110)
    • Over/Under (O/U): 36.5 (O: -110 | U: -110)

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    Cardinals at Colts picks and predictions

    Prediction

    Cardinals 23, Colts 20

    Neither team will play their starters this weekend. It will be a battle of backups and guys just trying to make an NFL roster.

    There is never a reliable way to handicap preseason games. They are volatile.

    The only way to bet the preseason is to simply take the plus odds on the moneyline on a few games and hope you hit at least half of them.

    BET CARDINALS (+110).

    Again, with games being decided late by players who largely won’t be on NFL rosters next month, there is no way to feel confident in a winning outcome, especially when no starters will play.

    PASS.

    The Cardinals only allowed 16 points last week and only scored 14, but all 14 came in the 2nd half.

    The Colts allowed 34 last week. There are concerns with their defensive depth.

    With no starters playing, expect both teams to be in the 20s.

    BET OVER 36.5 (-110).

    Play our free daily Pick’em Challenge and win! Play now!

    For more sports betting picks and tips

    SportsbookWire.com and BetFTW.

    Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

    Access more NFL coverage:

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