Buffalo Bills at Pittsburgh Steelers odds, picks and predictions

The Buffalo Bills (0-1) visit the Pittsburgh Steelers (0-1) Saturday night in Week 2 of the preseason. Kickoff from Acrisure Stadium is scheduled for 7 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the Bills vs. Steelers odds , and make our expert NFL picks and predictions .

Buffalo opened its preseason with a 33-6 loss against the Chicago Bears while failing to cover as a 3.5-point home favorite. QB Josh Allen started the game and went 2 of 3 for 22 yards, while QB Mitch Trubisky saw a majority of the snaps and went 10 of 18 for 82 yards.

The Steelers dropped their first game with a 20-12 loss against the Houston Texans while failing to cover as 3.5-point home favorites. QB Justin Fields saw minimal action going 5 of 6 for 67 yards, and QB Kyle Allen played the rest of the way and went 17 of 23 for 193 yards with a touchdown and interception.

Bills at Steelers odds

Provided by BetMGM Sportsbook ; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:20 a.m. ET.

• Moneyline (ML) : Bills +115 (bet $100 to win $115) | Steelers -135 (bet $135 to win $100)
• Against the spread (ATS) : Bills +1.5 (-110) | Steelers -1.5 (-110)
• Over/Under (O/U) : 38.5 (O: -115 | U: -105)

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Bills at Steelers picks and predictions

Prediction

Steelers 27, Bills 16

Moneyline

PASS .

The Steelers (-135) have a more commanding offense, but anything is possible in the preseason, so it may be worth a sprinkle on the Bills (+115).

Against the spread

BET PITTSBURGH -1.5 ( -110 ).

With QB Russell Wilson set to see playing time for Pittsburgh Saturday, followed by Fields and Allen, expect a quick start against the Bills. The Buffalo defense allowed 33 points in Week 1 and has not made the changes to adjust quickly enough against two 1st-team caliber quarterbacks who are capable of captaining high-octane offenses.

Over/Under

BET OVER 38.5 ( -110 ).

In their respective openers, both teams allowed a combined 53 points on defense. While both defenses should settle in a bit in Week 2, the offensive production for both should, as well. Expect Pittsburgh to carry more of the load, but both offenses should produce more points Saturday.

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